Caco-2 cells are human epithelial colorectal adenocarcinoma cells that, upon differentiation, express numerous morphological and biochemical characteristics of small intestinal enterocytes. This in vitro model is widely used to study mineral bioavailability from different sources and their transport mechanisms [ 12]. These statements have not been evaluated by any official health authority. These products are not intended to diagnose, treat, cure, or prevent any disease.

Many thanks for getting in touch. Yes, magnesium is a natural nerve and muscle relaxant that settles the nervous system - something that will help this worsening of your tinnitus. Our Marine Magnesium is from marine algae, so 100% natural, with some organic prebiotic added for gut health. The dose is 1 capsule daily, we tend to advise this to be taken in the evening for maximum relaxation - take one capsule in the evening Magnesium is in the spot light as its importance in health and well being becomes increasingly recognized. Approximately 50% of the body’s total magnesium is found in the bone. The other 50% is found in the tissues and organs with only 1% found in the blood. However, the body works very hard to keep this level constant in the blood as magnesium is vital to life. It is an essential component of DNA and is necessary for over 300 metabolic reactions in the body. It helps maintain normal nerve and muscle function, normal heart rhythm, normal neuromuscular conduction, normal blood pressure, and maintains bone integrity as well as glucose and insulin metabolism. The increased interest is due to magnesium’s many functions within the body and its associated role in disease prevention and overall health. Low levels of magnesium for health have been associated with a number of chronic diseases including migraine, headaches, Alzheimer’s disease, stroke, hypertension, cardiovascular disease and type2 diabetes. The market currently offers various supplement preparations to reach the recommended magnesium daily intake. These supplements differ in the type of magnesium salt used which can be either organic (i.e., magnesium citrate and magnesium aspartate) or inorganic (i.e., MgO and MgCl 2), their dosage and bioavailability. For example, magnesium from MgCl 2 has high bioavailability equivalent to organic magnesium supplements such as magnesium lactate and aspartate [ 7]. Moreover, these three sources of magnesium have significantly greater bioavailability than MgO [ 7]. Magnesium derived from magnesium hydroxide (Mg(OH) 2) (Mablet) has been shown to be absorbed into the circulation and, hence, bioavailable in healthy male adults [ 8]. In a previous study, the bioavailability of magnesium from formulations containing different combinations of magnesium salts displayed similar bioavailability, however the daily dose of magnesium differed [ 9]. Forms of magnesium that dissolve well in liquid are better absorbed in the gut than less soluble forms. 12 10 of the best magnesium supplements UK

I’ve been taking a magnesium tablet on and off for about a year. I note however you recommend your brand to be taken in the morning. Why is that? supplements are increasingly being used. The quality of the magnesium depends not only on its source, the magnesium content of the supplements, but also on its bio availability – that is the ability of magnesium to be absorbed and utilized by the body. Magnesium oxide traditionally has the highest magnesium content at 60% but also the lowest solubility while at the other end of the table below magnesium chloride and magnesium sulfate have the highest solubility but the lowest levels of magnesium. Magnesium hydroxide is the perfect balance possessing a high level of magnesium and 50% higher solubility than magnesium oxide in water (.009g/l vs .006g/l) Furthermore, it is soluble in stomach acid allowing absorption into the blood stream. Indeed, magnesium oxide must convert to magnesium hydroxide before dissolution in acid can begin.

We recommend taking Marine Magnesium each evening to help settle the nervous system in readiness for a good night sleep. This is a 100% natural magnesium from algae and the dose is 1 capsule each evening. Magnesium is a nerve and muscle relaxant which can bring relief from both cramping and restless limbs that may be preventing good quality sleep and also just to dial the nervous system down to allow you to maintain a goods nights sleep.

Despite the essential nature of magnesium there is no specific food that provides a high amount of magnesium. Good sources of magnesium for health includes whole grains, spinach, nuts, legumes and potatoes. However, even with the wide availability of magnesium in foods at least 60% and possibly as much as 80% of adults do not consume the recommended dietary intake (Rdi) for magnesium (310-420mg/day). ln addition, absorption of magnesium from the small intestine decreases and excretion by the kidneys increases as we age. Symptoms of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue and weakness. REVOLUTIONARY ECO-FRIENDLY, PULLULAN CAPSULES. Many cheaper supplements use capsules made from plant cellulose which goes through heavy processing and produces non-environmentally friendly, harmful bi-products. Pullulan is the next generation in encapsulation, derived from tapioca and processed with water. If you breach these conditions and we take no action, we will still be entitled to use our rights and remedies in any other situation where you breach these conditions. Governing Law and Jurisdiction The solubility of magnesium in the gastrointestinal tract plays a key role in magnesium absorption. Our bioaccessiblity results demonstrate that magnesium from Aquamin-Mg is soluble as MgCl 2 and hence potentially available for absorption. Our bioavailability data support that Mg(OH) 2, derived from Aquamin-Mg, displays a similar profile and transport characteristics as magnesium derived from MgCl 2 at the same concentrations, suggesting that Aquamin-Mg represents a source of magnesium coupled with potential health benefits of a multimineral supplement. Currently, however, as Aquamin-Mg is not formulated as an oral supplement (tablets and capsules), further comparisons with other formulated magnesium supplements were not possible. Even though calcium seems to get all the credit for keeping our bones healthy, magnesium is also very important. It plays a key role in the structural development of our bones and teeth. 4

MgCl 2 and MgO represent a high bioavailable and low bioavailable source of magnesium respectively, and our in vitro data are in keeping with in vivo data demonstrating that the mean urinary excretion of magnesium in healthy volunteers was significantly higher for MgCl 2 than MgO [ 7]. Interestingly, in this study, MgCl 2 bioavailability was comparable to that of organic magnesium forms such as magnesium aspartate and magnesium lactate [ 7]. The NHS recommends that you get the magnesium you need through your diet. 3However, if you want to enjoy the ‘insurance’ of a mineral supplement or are more prone to magnesium deficiency we’ve got youcovered.There are many types of magnesium, but the few that are most commonly used to make magnesium supplement are called 10: Your relationship with Time Health Ltd is governed by and construed in accordance with the laws of the United Kingdom. You agree, as we do, to submit to the non-exclusive jurisdiction of the Courts of the United Kingdom. Magnesium is essential for transporting energy to all the cells in your body, so if you’re running low in this mineral, you can feel excessively tired and fatigued for seemingly ‘no reason’.